Scientists discover pathways to severe COVID-19 in children

Researchers discover pathways that are activated in severe cases of COVID-19 in childrenan advance that could lead to earlier diagnosis and more targeted therapies for Illness. The study, published in Nature Communications, identified disease mechanisms in children with COVID-19 who suffer from multisystem inflammatory syndrome, in which different parts of the body can become inflamed including the heart, lungs, brain and acute. Respiratory distress Syndrome, a type of lung disease.

The main causes of severe COVID-19 in children were blood clotting and how proteins are in immune system reaction to the virus, the researchers said. “Children in general are less likely to get COVID-19 and present with milder symptoms, but it is still not clear why some become so ill,” said Conor McCafferty, a doctoral student at the University of Melbourne in Australia.

“Our research was the first of its kind to reveal the specific blood clotting and immune protein pathways that affected children with COVID-19 who developed severe symptoms,” McCafferty said in a statement. For the study, blood samples were collected from 20 healthy children and samples from 33 SARS-CoV-2 Infected children with multiple systems inflammatory syndrome or acute respiratory distress syndrome.

Professor Damien Bonnet, of the Université Générale Hospitals of Paris, France, said that collecting samples to further characterize the mechanisms of these syndromes and establish global collaboration are key issues for improving treatment and outcomes. The research found that 85 and 52 proteins were specific for multisystem inflammatory syndrome and acute respiratory distress syndrome, respectively. Both syndromes are major potential outcomes of severe COVID-19.

The data shows that 1.7 percent of hospitalized pediatric cases of COVID-19 included admissions to the intensive care unit, according to the researchers.

Children with COVID-19 with MIS also show clinical features similar to Kawasaki disease and toxic shock syndrome such as fever, Stomach achevomiting Skin rash and conjunctivitis, making it difficult to diagnose patients quickly.

“The results provided an understanding of the processes that lead to severe COVID-19 infection in children, which should aid the development of diagnostic tests for the early identification of Children are in dangerand therapeutic targets to improve outcomes for those with severe cases,” said Professor Vera Ignatovic of the Murdoch Children’s Research Institute (MCRI) in Australia.

“Knowing the mechanisms associated with severe COVID-19 in children and how blood clotting and the children’s immune system interact with the virus will help diagnose and detect severe COVID-19 cases and allow us to develop targeted therapy,” Ignatovic added.

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